Among endocrine diseases, thyroid diseases occupy the highest places in the world in terms of incidence. A number of targeted scientific studies are being conducted around the world to study the functional structure of the thyroid gland depending on age and gender. In this regard, it is necessary to study the factors leading to the development of hypothyroid syndrome in pathology of the thyroid gland, especially the state of hypothyroidism during pregnancy, the negative impact of hypothyroidism on fetal development, including the risk of serious pathological changes. In the musculoskeletal system, changes in the shape of the musculoskeletal system can lead to severe, potential disability of the growing organism. Degenerative-dystrophic changes in this area are of particular scientific and practical importance.